Effect of Ganoderma lucidum Spores and Propolis Complex on Immune Function in Mice
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摘要: 目的:研究灵芝孢子粉蜂胶复合物对小鼠免疫功能的影响。方法:将雌性昆明鼠随机分成空白对照组和低、中、高剂量组,每组10只,分别灌胃给予蒸馏水、灵芝孢子粉蜂胶75、150和450 mg/kg bw。30 d后测定小鼠体重、免疫脏器指数、碳粒廓清能力、腹腔巨噬细胞吞噬鸡红细胞能力、脾淋巴细胞增殖能力、迟发型变态反应(DTH)和血清溶血素水平。结果:与对照组相比,中、高剂量能显著增强小鼠腹腔巨噬细胞吞噬鸡红细胞能力和脾淋巴细胞增殖能力(p<0.05)、极显著提高小鼠血清溶血素水平和迟发型变态反应和脾淋巴细胞增殖能力(p<0.01),而低剂量能显著(p<0.05)提高小鼠血清溶血素水平。结论:灵芝孢子粉蜂胶复合物具有增强小鼠免疫功能的作用。Abstract: Objective:To study the effect of Ganoderma lucidum spores and propolis complex on immune function in mice. Methods:The female kunming mice were randomly divided into blank control, low-, medium-and high-dose groups, each group of ten. The mice were administrated with distilled water or Ganoderma lucidum spores and propolis complex for 75, 150 and 450 mg/kg bw, respectively.After 30 days, the following experiments were conducted:Body weight, immune organ index, carbon clearance ability, peritoneal macrophage phagocytosis ability, spleen lymphocyte proliferation ability, delayed-type hypersensitivity and serum hemolysin capacity. Results:Compared with the control group, peritoneal macrophage phagocytosis ability and spleen lymphocyte proliferation ability increased significantly (p<0.05) at the dose of medium and high. Serum hemolysin capacity and delayed-type hypersensitivity response and spleen lymphocyte proliferation ability increased highly significantly (p<0.01) at the dose of medium and high. Serum hemolysin capacity increased significantly at the dose of low (p<0.05).Conclusion:Ganoderma lucidum spores and propolis complex can promote the immune function in mice.
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Keywords:
- Ganoderma lucidum spores /
- propolis /
- complex /
- immune function
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