菊苣仔根提取物对高脂血症仓鼠血脂的影响
详细信息Effect of Chicory Root extract on blood lipid in hyperlipemia hamsters
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摘要: 探讨菊苣仔根提取物的降血脂功效。将雄性仓鼠随机分为6组,分别为空白组、模型组、添加菊苣仔根水提物及醇提物低、高剂量组（高脂饲料中质量分数均分别为1.0%、5.0%）,饲养6周后对仓鼠进行眼底静脉丛采血,并检测相关指标。结果显示,与高脂模型组相比,添加菊苣仔根水提物及醇提物的低、高剂量组仓鼠血清中的总胆固醇（TC）、甘油三酯（TG）及非高密度脂蛋白胆固醇（non-HDL-C）水平均极显著降低（p<0.01）,水提物和醇提物高剂量组高密度脂蛋白胆固醇（HDL-C）水平呈极显著和显著升高（p<0.01）、（p<0.05）,水提物低、高剂量组和醇提物高剂量组仓鼠血清和肝脏中的MDA含量均呈不同程度的降低。结论:菊苣仔根水提物和醇提物对高脂血症仓鼠血脂水平均具有降低作用,并有抑制脂质过氧化的作用。醇提物在降低总胆固醇（TC）、甘油三酯（TG）水平方面略优于水提物,而水提物对于高密度脂蛋白胆固醇（HDL-C）水平的升高作用则更加明显。Abstract: To investigate the effect of chicory root extract on lowering blood lipid.The male hamsters were divided into 6 groups, including the normal group, the model group, intervention groups administered with water extract and alcohol extract of chicory root at doses of 1.0% and 5.0%.Hyperlipidemic indicators were tested after collecting serum samples.Results:Compared with the model group, the concentration of total cholesterol (TC) , triglyceride (TG) and non-high density lipoprotein cholesterol (non-HDL-C) in serum exhibited a significant decrease in serum from the low-dose and high-dose group of water extract and alcohol extract of chicory root (p<0.01) .The concentration of high density lipoprotein cholesterol (HDL-C) in serum exhibited a significant increase and a increase from high-dose group of water extract and high-dose group of alcohol extract (p<0.01) , (p<0.05) .The content of MDA was decreased in serum and liver in the low-dose and high-dose group of water extract and the high-dose group of alcohol extract.Conclusion:Water extract and alcohol extract of chicory root had an obvious effect on lowering blood lipid and inhibiting lipid peroxidation in hyperlipemia hamsters.The effect of lowering total cholesterol (TC) and triglyceride (TG) with alcohol extract was better than water extract.On the other hand, the effect of heightening high density lipoprotein cholesterol (HDL-C) with water extract was more obvious than alcohol extract.
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