Optimization of Preparation Process for Nanostructured Lipid Carrier of CBD Broad-Spectrum Oil by Response Surface Methodology

MA Yongqiang; TANG Kexin; YU Shiyou; WANG Xin; PENG Yu

doi:10.13386/j.issn1002-0306.2021070339

Volume 43 Issue 7

Mar. 2022

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Science and Technology of Food Industry > 2022 > 43(7): 206-213. > DOI: 10.13386/j.issn1002-0306.2021070339

MA Yongqiang, TANG Kexin, YU Shiyou, et al. Optimization of Preparation Process for Nanostructured Lipid Carrier of CBD Broad-Spectrum Oil by Response Surface Methodology[J]. Science and Technology of Food Industry, 2022, 43(7): 206−213. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021070339.

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Optimization of Preparation Process for Nanostructured Lipid Carrier of CBD Broad-Spectrum Oil by Response Surface Methodology

1.
College of Food Engineering, Harbin University of Commerce, Harbin 150028, China
2.
Harbin Hanbo Technology Development Co., Ltd., Harbin 150028, China

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Received Date: July 27, 2021
Available Online: February 09, 2022

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Abstract

Abstract

CBD-NLC was prepared by film ultrasonic method with soybean phospholipid and cholesterol as solid esters. The effects of mass ratio of phospholipid to cholesterol, mass concentration of CBD broad-spectrum oil, pH value of buffer solution, rotary evaporation temperature and ultrasonic time on the encapsulation efficiency of CBD-NLC were analyzed by single factor experiment, The four factors which have great influence on the preparation of CBD-NLC were optimized by response surface test. The results showed that the optimum preparation conditions were as follows: the mass ratio of phospholipid to cholesterol was 3.4:1, the mass concentration of CBD broad-spectrum oil was 9.5%, the pH of buffer solution was 7.3, the rotary evaporation temperature was 39.1 ℃, and the ultrasonic time was 30 min. The results showed that the encapsulation efficiency of CBD-NLC was (91.3%±0.37%), the particle size was (94.0±0.4) nm, the PDI was (0.213±0.017), the zeta potential was (−45.0±0.8) mV. The color of CBD-NLC suspension is light yellow, with good dispersion uniformity and stability, which lays a foundation for the further development and application of CBD broad-spectrum oil.
- CBD broad-spectrum oil,
- nanostructured lipid carrier,
- preparation technology,
- response surface method

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Science and Technology of Food Industry

Optimization of Preparation Process for Nanostructured Lipid Carrier of CBD Broad-Spectrum Oil by Response Surface Methodology

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