WANG Jialuan, ZHAO Fengyi, ZHANG Chunhong, et al. Research Progress of Extraction, Purification and Bioactivity of Ellagic Acid[J]. Science and Technology of Food Industry, 2022, 43(13): 416−424. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021060276.
Citation: WANG Jialuan, ZHAO Fengyi, ZHANG Chunhong, et al. Research Progress of Extraction, Purification and Bioactivity of Ellagic Acid[J]. Science and Technology of Food Industry, 2022, 43(13): 416−424. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021060276.

Research Progress of Extraction, Purification and Bioactivity of Ellagic Acid

More Information
  • Received Date: July 01, 2021
  • Available Online: April 20, 2022
  • Plant kingdom is rich in many kinds of natural substances which are beneficial to human health and play a certain auxiliary function to human health. Ellagic acid is a natural polyphenol dilactone found in many fruits and nuts. It has antioxidant, anti-inflammatory, inhibition of bacterial growth and other biological activities, and has great application potential in cancer treatment and disease prevention. Many scholars at home and abroad have conducted in-depth studies on the biological activities of ellagic acid, which has a wide application prospect in the treatment of human diseases, tumors and production and life. In this paper, the extraction and purification methods of ellagic acid, as well as the studies on anti-cancer, anti-oxidation, anti-inflammation and other biological activities of ellagic acid were summarized, providing certain reference for the subsequent research on ellagic acid.
  • loading
  • [1]
    ROMMEL A, WROLSTAD R. Ellagic acid content of red raspberry juice as influenced by cultivar, processing, and environmental factors[J]. Journal of Agricultural and Food Chemistry,1993,41(11):1951−1960. doi: 10.1021/jf00035a026
    [2]
    骆菊文, 蒋新元, 徐佳敏, 等. 鞣花酸的稳定性及其保护研究[J]. 日用化学工业,2020,50(8):547−552. [LUO J W, JIANG X Y, XU J M, et al. Study on the stability and protection of ellagic acid[J]. China Surfactant Detergent & Cosmetics,2020,50(8):547−552. doi: 10.3969/j.issn.1001-1803.2020.08.007

    LUO J W, JIANG X Y, XU J M, et al. Study on the stability and protection of ellagic acid[J]. China Surfactant Detergent & Cosmetics, 2020, 50(8): 547-552. doi: 10.3969/j.issn.1001-1803.2020.08.007
    [3]
    张立华, 郝兆祥, 董业成. 石榴的功能成分及开发利用[J]. 山东农业科学,2015,47(10):133−138. [ZHANG L H, HAO Z X, DONG Y C. Functional components and development and utilization of pomegranate[J]. Shandong Agricultural Sciences,2015,47(10):133−138.

    ZHANG L H, HAO Y X, DONG Y C. Functional components and development and utilization of pomegranate[J]. Shandong Agricultural Sciences, 2015, 47(10): 133-138.
    [4]
    吴小磊, 钟晨, 史金铭. 鞣花酸的生物学效应[J]. 中国林副特产,2019(1):73−78. [WU X L, ZHONG C, SHI J M. Biological effect of ellagic acid[J]. Forest by-Product and Speciality in China,2019(1):73−78.

    WU X L, ZHONG C, SHI J M. Biological effect of ellagic acid[J]. Forest by-product and Speciality in China, 2019(1): 73-78.
    [5]
    MAAS J L, WANG S Y, GALLETTA G J. Evaluation of strawberry cultivars for ellagic acid content[J]. Hort Science,1991,26(1):66−68.
    [6]
    MAR L, ANTONIO G, TERESA G M, et al. Urolithins, ellagic acid-derived metabolites produced by human colonic microflora, exhibit estrogenic and antiestrogenic activities[J]. Journal of Agricultural and Food Chemistry,2006,54(5):1611−1620. doi: 10.1021/jf0527403
    [7]
    李素琴, 袁其朋, 徐健梅. 鞣花酸的生理功能及工艺开发研究现状[J]. 天然产物研究与开发,2001,13(5):71−74,79. [LI S Q, YUAN Q P, XU J M. The physiological function of ellagic acid and the research development on its production process[J]. Natural Product Research and Development,2001,13(5):71−74,79. doi: 10.3969/j.issn.1001-6880.2001.05.021

    LI S Q, YUAN Q P, XU J M. The physiological function of ellagic acid and the research development on its production process[J]. Natural Product Research and Development, 2001 (5): 71-74, 79. doi: 10.3969/j.issn.1001-6880.2001.05.021
    [8]
    UST A, OZDEMI R, SCHIARIT I, et al. The pharmacological use of ellagic acid-rich pomegranate fruit[J]. International Journal of Food Sciences and Nutrition,2013,64(7):907−913. doi: 10.3109/09637486.2013.798268
    [9]
    SAYEDALIREZA M, SAYEDMOJTABA M. Benefits of ellagic acid from grapes and pomegranates against colorectal cancer[J]. Caspian Journal of Internal Medicine,2017,8(3):226−227.
    [10]
    XU Y, CHARLES M T, LUO Z, et al. Preharvest ultraviolet C irradiation increased the level of polyphenol accumulation and flavonoid pathway gene expression in strawberry fruit[J]. Journal of Agricultural and Food Chemistry,2017,65(46):9970−9979. doi: 10.1021/acs.jafc.7b04252
    [11]
    DANH V C, PHUC V H, MARK C V, et al. Identification and characterization of phenolic compounds in black walnut kernels[J]. Journal of Agricultural and Food Chemistry,2018,66(17):4503−4511. doi: 10.1021/acs.jafc.8b01181
    [12]
    BALA I, BHARDWAJ V, HARIHARAN S, et al. Analytical methods for assay of ellagic acid and its solubility studies[J]. Journal of Pharmaceutical and Biomedical Analysis,2006,40(1):206−210. doi: 10.1016/j.jpba.2005.07.006
    [13]
    KILIC K, YEŞIM Y, BAYRAK Y. Spectroscopic studies on the antioxidant activity of ellagic acid[J]. Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy,2014,130:477−452.
    [14]
    SYED U, PONNURAJ N, GANAPASAM S. Ellagic acid inhibits proliferation and induced apoptosis via the Akt signaling pathway in HCT-15 colon adenocarcinoma cells[J]. Molecular and Cellular Biochemistry,2015,399(1-2):303−313. doi: 10.1007/s11010-014-2257-2
    [15]
    SRIGOPALRAM S, JAYRAAJ I A, KALEESWARAN B, et al. Ellagic acid normalizes mitochondrial outer membrane permeabilization and attenuates inflammation-mediated cell proliferation in experimental liver cancer[J]. Applied Biochemistry and Biotechnology,2014,173(8):2254−2266. doi: 10.1007/s12010-014-1031-y
    [16]
    段婧. 鞣花酸对非小细胞肺癌的抑制作用及机制研究[D]. 北京: 中国农业大学, 2018

    DUAN J. Ellagic acid exert anti-non-small cell lung cancer activity in vitro and in vivo[D]. Beijing: China Agricultural University, 2018.
    [17]
    SHI L, GAO X, LI X, et al. Ellagic acid enhances the efficacy of PI3K inhibitor GDC-0941 in breast cancer cells[J]. Current Molecular Medicine,2015,15(5):478−486. doi: 10.2174/1566524015666150505161046
    [18]
    王丹, 王悦欣, 汪熠, 等. 鞣花酸对皮肤基底细胞癌A431和HSC-2细胞增殖、凋亡、侵袭能力的影响[J]. 癌症进展,2020,18(4):356−358,432. [WANG D, WANG Y X, WANG Y, et al. Effects of ellagic acid on proliferation, apoptosis and invasion of human basal cell carcinoma A431 and HSC-2[J]. Oncology Progress,2020,18(4):356−358,432.

    WANG D, WANG Y X, WANG Y, et al. Effects of ellagic acid on proliferation, apoptosis and invasion of human basal cell carcinoma A431 and HSC-2[J]. Oncology Progress, 2020, 18(4): 356- 358, 432.
    [19]
    SEERAM N P, HENNING S M, ZHANG Y J, et al. Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 h[J]. The Journal of Nutrition,2006,136(10):2481−2485. doi: 10.1093/jn/136.10.2481
    [20]
    KHAC D D, TRAN-VAN S, CAMPOS A M, et al. Ellagic compounds from Diplopanax stachyanthus[J]. Pergamon,1990,29(1):251−256.
    [21]
    邸幼军, 贾光锋. 超声强化提取石榴皮鞣花酸的工艺研究[J]. 现代生物医学进展,2010,10(19):3703−3705. [DI Y J, JIA G F. Study on the ultrasonic extraction process of ellagic acid from pomegranate husk[J]. Progress in Modern Biomedicine,2010,10(19):3703−3705.

    DI Y J, JIA G F. Study on the ultrasonic extraction process of ellagic acid from pomegranate husk[J]. Progress in Modern Biomedicine, 2010, 10(19): 3703-3705.
    [22]
    李小萍. 红树莓果中鞣花酸的提取、纯化及抗氧化性和抑菌活性的初步研究[D]. 兰州: 甘肃农业大学, 2010

    LI X P. Study on extraction, refining and oxidationresistant and antimicrobiall effects of ellagic acid from red raspberry[D]. Lanzhou: Gansu Agricultural University, 2010.
    [23]
    王佳慧, 于欣悦, 廖声玲, 等. 树莓中鞣花酸提取工艺的优化[J]. 中国林副特产,2017(4):14−17. [WANG J H, YU X Y, LIAO S L, et al. Optimization of extraction process of ellagic acid from raspberry[J]. Forest by-production and Speciality in China,2017(4):14−17.

    WANG J H, YU X Y, LIAO S L, et al. Optimization of extraction process of ellagic acid from raspberry[J]. Forest by-production and Speciality in China, 2017 (4): 14-17.
    [24]
    LU J, YUAN Q. A new method for ellagic acid production from pomegranate husk[J]. Journal of Food Process Engineering,2008,31(4):443−454. doi: 10.1111/j.1745-4530.2007.00169.x
    [25]
    VATTEM D A, SHETTY K. Ellagic acid production and phenolic antioxidant activity in cranberry pomace (Vaccinium macrocarpon) mediated by Lentinus edodes using a solid-state system[J]. Process Biochemistry,2003,39(3):367−379. doi: 10.1016/S0032-9592(03)00089-X
    [26]
    徐涓, 张弘, 李坤, 等. 液气射流技术改进单宁酸氧化制备高纯度鞣花酸[J]. 精细化工,2021,38(5):994−1001,1037. [XU J, ZHANG H, LI K, et al. Improved tannic acid oxidation by liquid-gas jet technology for preparation of high purity ellagic acid[J]. Fine Chemicals,2021,38(5):994−1001,1037.

    XU J, ZHANG H, LI K, et al. Improved tannic acid oxidation by liquid-gas jet technology for preparation of high purity ellagic acid[J]. Fine Chemicals, 2021, 38 (05): 994-1001, 1037.
    [27]
    王佳宁. 蓝靛果鞣花酸分离纯化及对脂质过氧化作用的影响研究[D]. 哈尔滨: 哈尔滨商业大学, 2018

    WANG J N. Separation and purification of ellagic acid of and its effect on lipid peroxidation in Lonicera caerulea L.[D]. Harbin: Harbin University of Commerce, 2018.
    [28]
    郝少莉, 陈小蒙, 仇学农. 苹果渣中多酚物质的纯化及其抑菌活性的研究[J]. 食品科学,2007,28(11):86−90. [HAO S L, CHEN X M, QIU X N, et al. Study on purification and antimicrobial activity of polyphenols in apple pomace[J]. Food Scence,2007,28(11):86−90. doi: 10.3321/j.issn:1002-6630.2007.11.014

    HAO S L, CHEN X M, QIU X N, et al. Study on purification and antimicrobial activity of polyphenols in apple pomace[J]. Food Scence, 2007, 28(11): 86-90. doi: 10.3321/j.issn:1002-6630.2007.11.014
    [29]
    吴梦琪, 黄海, 蔡狄宏, 等. 大孔吸附树脂-高速逆流色谱法分离纯化苦水玫瑰花渣中的鞣花酸[J]. 食品工业科技,2021,42(5):182−187. [WU M Q, HUANG H, CAI D H, et al. Separation and purification of ellagic acid from rosa setate x rosa rugosa waste by macroporous resin and high-speed countercurrent chromatography[J]. Science and Technology of Food Industry,2021,42(5):182−187.

    WU M Q, HUANG H, CAI D H, et al. Separation and purification of ellagic acid from rosa setate x rosa rugosa waste by macroporous resin and high-speed countercurrent chromatography[J]. Science and Technology of Food Industry, 2021, 42(5): 182-187.
    [30]
    杨光, 周双, 孙兰英, 等. HPLC法测定秋果型树莓不同部位鞣花酸的含量[J]. 黑龙江农业科学,2021(3):86−89. [YANG G, ZHOU S, SUN L Y, et al. Determination of ellagic acid in different part of raspberry by HPLC[J]. Heilongjiang Agricultural Science,2021(3):86−89.

    YANG G, ZHOU S, SUN L Y, et al. Determination of ellagic acid in different part of raspberry by HPLC[J]. Heilongjiang Agricultural Science, 2021(3): 86 - 89.
    [31]
    FERNANDES A, RIBEIRO A R, MONTEIRO M, et al. Secretome from SH-SY5Y APP Swe cells trigger time-dependent CHME3 microglia activation phenotypes, ultimately leading to miR-21 exosome shuttling[J]. Biochimie,2018:67−82.
    [32]
    LEHNARDT S. Innate immunity and neuroinflammation in the CNS: The role of microglia in Toll-like receptor‐mediated neuronal injury[J]. Glia,2010,58(3):43−52.
    [33]
    GRAEBER M B, STREIT W J. Microglia: Biology and pathology[J]. Acta Neuropathologica,2010,119(1):89−105. doi: 10.1007/s00401-009-0622-0
    [34]
    GONÇALO G, FARIA P T, PAULA P, et al. Bioaccessible raspberry extracts enriched in ellagitannins and ellagic acid derivatives have anti-neuroinflammatory properties[J]. Antioxidants,2020,9(10):790.
    [35]
    吕广. 鞣花酸对脂多糖诱导的炎症反应的抑制作用和机制研究[D]. 长春: 吉林大学, 2016

    LYU G. Inhibitory effects and mechanisms of ellagic acid on lipopolysaccharide-induced inflammation[D]. Changchun: Jilin University, 2016.
    [36]
    SIMON J P, PRINCE S E. Aqueous leaves extract of Madhuca longifolia attenuate diclofenac-induced hepatotoxicity: Impact on oxidative stress, inflammation, and cytokines[J]. Journal of Cellular Biochemistry,2018,119(7):6125−6135. doi: 10.1002/jcb.26812
    [37]
    ZARAGOZA M A, ALFONSO M V, ROIG C E. NSAID-induced hepatotoxicity: Aceclofenac and diclofenac[J]. Revista Espanola de Enfermedades Digestivas: Organo Oficial de la Sociedad Espanola de Patologia Digestiva,1995,87(6):472−475.
    [38]
    ASHUTOSH G, PANDEY A K. Aceclofenac-induced hepatotoxicity: An ameliorative effect of Terminalia bellirica fruit and ellagic acid[J]. World Journal of Hepatology,2020,12(11):949−964. doi: 10.4254/wjh.v12.i11.949
    [39]
    VALKO M, LEIBFRITZ D, MONCOL J, et al. Free radicals and antioxidants in normal physiological functions and human disease[J]. Biochem Cell Biol,2007,39:44−84. doi: 10.1016/j.biocel.2006.07.001
    [40]
    HALLIWELL B. Free radicals, antioxidants, and human disease: Curiosity, cause, or consequence[J]. Lancet,1994,344(8924):721−724. doi: 10.1016/S0140-6736(94)92211-X
    [41]
    KUREK-GÓRECKA A, RZEPECKA-STOJKO A, GÓRECKI M, et al. Structure and antioxidant activity of polyphenols derived from propolis[J]. Molecules 2014, 19: 78–101.
    [42]
    崔珊珊, 毕凯媛, 吴杰, 等. 响应面法优化树莓鞣花酸提取工艺及其体外抗氧化活性[J]. 食品工业科技,2019,40(1):149−155,161. [CUI S S, BI K Y, WU J, et al. Optimization of extraction technology and antioxidative activity of ellagic acid in raspberry by response surface methodology[J]. Science and Technology of Food Industry,2019,40(1):149−155,161.

    CUI S S, BI K Y, WU J, et al. Optimization of extraction technology and antioxidative activity of ellagic acid in raspberry by response surface methodology[J]. Science and Technology of Food Industry, 2019, 40 (1): 149-155, 161.
    [43]
    蒋新龙, 吴小刚, 郭叶莹, 等. 鞣花酸磷脂复合物制备及其对植物油抗氧化作用[J]. 中国粮油学报,2021,36(2):81−88. [JIANG X L, WU X G, GUO Y Y, et al. Preparation of ellagic acid phospholipid complex and its antioxidative effect on vegetable oil[J]. Journal of the Chinese Cereals and Oils Association,2021,36(2):81−88. doi: 10.3969/j.issn.1003-0174.2021.02.014

    JIANG X L, WU X G, GUO Y Y, et al. Preparation of ellagic acid phospholipid complex and its antioxidative effect on vegetable oil[J]. Journal of the Chinese Cereals and Oils Association, 2021, 36(2): 81-88. doi: 10.3969/j.issn.1003-0174.2021.02.014
    [44]
    NIZAR A, QOSAY A, MOHAMMAD A, et al. Ellagic acid: A potent glyoxalase-I inhibitor with unique scaffold[J]. Acta Pharmaceutica,2021,71(1):115−130. doi: 10.2478/acph-2021-0005
    [45]
    SUNG H, FERLAY J, SIEGEL R L, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA: A Cancer Journal for Clinicians,2021,71(3):209−249. doi: 10.3322/caac.21660
    [46]
    GUKOVSKAYA A S, PANDOL S J. Cell death pathways in pancreatitis and pancreatic cancer[J]. Pancreatology,2004,4(6):567−586. doi: 10.1159/000082182
    [47]
    MOUAD E, IRINA O, IZUMI O, et al. Ellagic acid induces apoptosis through inhibition of nuclear factor κB in pancreatic cancer cells[J]. World Journal of Gastroenterology,2008(23):3672−3680.
    [48]
    TAN Y H, SHUDO T, YOSHIDA T, et al. Ellagic acid, extracted from Sanguisorba officinalis, induces G1 arrest by modulating PTEN activity in B16F10 melanoma cells[J]. Genes to Cells,2019,24(11):688−704. doi: 10.1111/gtc.12719
    [49]
    AMANAM I, GUPTA R, MAMBETSARIEV I, et al. The brigatinib experience: A new generation of therapy for ALK-positive non-small-cell lung cancer[J]. Future Oncol,2018:0545.
    [50]
    KIM D W, TALATI C, KIM R. Hepatocellular carcinoma (HCC): Beyond sorafenib-chemotherapy[J]. Journal of Gastrointestinal Oncology,2017,8(2):256−265. doi: 10.21037/jgo.2016.09.07
    [51]
    WYLLY R G, CECILIA Z. Ellagic acid: Pharmacological activities and molecular mechanisms involved in liver protection[J]. Pharmacological Research,2015,97:84−103. doi: 10.1016/j.phrs.2015.04.008
    [52]
    ZHAO M, TANG S, JUSTIN L, et al. Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice[J]. Cancer Letters,2013,337(2):210−271. doi: 10.1016/j.canlet.2013.05.009
    [53]
    YUAN C, LI C, MING H, et al. The inhibitory effect of ellagic acid on cell growth of ovarian carcinoma cells[J]. Evidence-Based Complementary and Alternative Medicine,2013,2013:705−717.
    [54]
    RADHA M, FARRUKH A, MANICKA V, et al. MicroRNA ‘signature’ during estrogen-mediated mammary carcinogenesis and its reversal by ellagic acid intervention[J]. Cancer Letters,2013,339(2):175−184. doi: 10.1016/j.canlet.2013.06.012
    [55]
    钟晨. 鞣花酸抑制肝癌的分子机制及其与两种化疗药物协同作用的研究[D]. 哈尔滨: 东北林业大学, 2019

    ZHONG C. The mechanisms of ellagic acid against hepatocellular carcinoma and synergistic effects of its combinations with two chemotherapeutic agents[D]. Harbin: Northeast Forestry University, 2019.
    [56]
    NAROZHNYI S V, ROZANOVA K D, BOBROVA O M, et al. Antioxidant and antiradical efects of extracts derived from cryopreserved human placenta[J]. Probl Cryobiol Cryomed,2018,28(4):322−332. doi: 10.15407/cryo28.04.322
    [57]
    HIROSHI O, YUMIKO Y, SEBASTIEN A, et al. Antioxidant and pro-oxidant actions of flavonoids: Effects on DNA damage induced by nitric oxide, peroxynitrite and nitroxyl anion[J]. Free Radical Biology and Medicine,1998,25(9):1057−1065. doi: 10.1016/S0891-5849(98)00141-5
    [58]
    NATHAN S B, JOSEPH L. Nitrite and nitrate in human health and disease[M]. Humana Press: 2011-01-01.
    [59]
    ZHOU L, ZAHID M, ANWAR M M, et al. Suggestive evidence for the induction of colonic aberrant crypts in mice fed sodium nitrite.[J]. Nutrition and Cancer,2016,68(1):105−112. doi: 10.1080/01635581.2016.1102298
    [60]
    AMIRA R, TAREK M, EHAB M. Detoxifying and antioxidant effect of ellagic acid nano particles in rats intoxicated with sodium nitrites[J]. Applied Biological Chemistry,2020,63(1):322−332.
    [61]
    王德平, 毛晓春. 中药马兜铃酸的研究进展[J]. 北方药学,2014,11(11):97−98. [WANG D P, MAO X C. Research progress of aristolochic acid[J]. Journal of Narth Pharmacy,2014,11(11):97−98. doi: 10.3969/j.issn.1672-8351.2014.11.080

    WANG D P, MAO X C. Research progress of aristolochic acid[J]. Journal of Narth Pharmacy, 2014, 11(11): 97-98. doi: 10.3969/j.issn.1672-8351.2014.11.080
    [62]
    CHAN C K, LIU Y S, PAVLOVIĆ N M, et al. Etiology of balkan endemic nephropathy: An update on aristolochic acids exposure mechanisms[J]. Chemical Research in Toxicology,2018,31(11):1109−1110. doi: 10.1021/acs.chemrestox.8b00291
    [63]
    ZENG Y G, ZHENG L, YANG Z G, et al. Protective effects of cyclic helix B peptide on aristolochic acid induced acute kidney injury[J]. Biomedicine & Pharmacotherapy,2017,94:1167−1175.
    [64]
    付千. 鞣花酸对马兜铃酸Ⅰ诱导急性肾损伤的保护作用及其机制研究[D]. 武汉: 中南民族大学, 2020

    FU Q. Protective effect and mechanism of ellagic acid on aristolochic acid I induced acute renal injury[D]. Wuhan: South-Central University For Nationalities, 2020.
    [65]
    DING X, JIAN T, WU Y, et al. Ellagic acid ameliorates oxidative stress and insulin resistance in high glucose-treated HepG2 cells via miR-223/keap1-Nrf2 pathway[J]. Biomed Pharm,2019,110:85−94. doi: 10.1016/j.biopha.2018.11.018
    [66]
    FATIMA N, HAFIZUR R M, HAMEED A, et al. Ellagic acid in Emblica officinalis exerts anti-diabetic activity through the action on β-cells of pancreas[J]. European Journal of Nutrition,2017,56(2):591−601. doi: 10.1007/s00394-015-1103-y
    [67]
    MANNA K, MISHRA S, SAHA M, et al. Amelioration of diabetic nephropathy using pomegranate peel extract-stabilized gold nanoparticles: Assessment of NF-κB and Nrf2 signaling system[J]. International Journal of Nanomedicine,2019,14:1753−1777. doi: 10.2147/IJN.S176013
    [68]
    JOZAA Z, NORA A, REHAM I, et al. Ellagic acid protects against diabetic nephropathy in rats by regulating the transcription and activity of Nrf2[J]. Journal of Functional Foods,2021,79:397−407.
    [69]
    闫莉, 周晓英. 鞣花酸对变异链球菌的体外抑菌作用及机制研究[J]. 中国药房,2020,31(5):607−611. [YAN L, ZHOU X Y. Study on in vitro anti-bacterial activity and mechanism of ellagic acid on streptococcus mutans[J]. China Pharmacy,2020,31(5):607−611. doi: 10.6039/j.issn.1001-0408.2020.05.20

    YAN L, ZHOU X Y. Study on in vitro anti-bacterial activity and mechanism of ellagic acid on streptococcus mutans[J]. China Pharmacy, 2020, 31(5): 607-611. doi: 10.6039/j.issn.1001-0408.2020.05.20
    [70]
    郑进萍, 欧正阳, 曾圳, 等. 鞣花酸对IPEC-J2细胞凋亡及相关基因表达的影响[J]. 黑龙江畜牧兽医,2021(7):126−130, 158−159. [ZHENG J P, OU Z Y, ZENG C, et al. Effects of ellagic acid on apoptosis and apoptosis-related gene expression in IPEC-J2 cells[J]. Heilongjiang Animal Science and Veterinary Medicine,2021(7):126−130, 158−159.

    ZHENG J P, OU Z Y, ZENG C, et al. [J]. Heilongjiang Animal Science and Veterinary Medicine, 2021(7): 126-130+158-159.
    [71]
    吴家荣. 鞣花酸对IPEC-J2细胞保护作用的研究[D]. 福州: 福建农林大学, 2018

    WU J R. Study on the protective effect of ellagic acid in IPEC-J2 cells[D]. Fuzhou: Fujian Agriculture and Forestry University, 2018.
    [72]
    LETICIA T, ROCCHETTI S, MARIANA C, et al. Characterization of pomegranate peel extracts obtained using different solvents and their effects on cell cycle and apoptosis in leukemia cells[J]. Food Science & Nutrition,2020,8(10):5483−5496.
    [73]
    MAR L, MARÍA T, JUAN C. Ellagitannins, ellagic acid and vascular health[J]. Molecular Aspects of Medicine,2010,31(6):513−539. doi: 10.1016/j.mam.2010.09.005
    [74]
    柏宏伟, 成军, 杨柳, 等. 板栗雄花序萃取物抗氧化及抑菌效果[J]. 林业科学,2015,51(5):145−152. [BO H W, CHENG J, YANG L, et al. Antioxidation and antimicrobial activities of extracts parts of chestnut catkins[J]. Scientia Silvae Sinicae,2015,51(5):145−152.

    BO H W, CHENG J, YANG L, et al. Antioxidation and antimicrobial activities of extracts parts of chestnut catkins[J]. Scientia Silvae Sinicae, 2015, 51(5): 145-152.
    [75]
    CARLOS E, BARRIO G, BEGOÑA C, et al. Iberian pig as a model to clarify obscure points in the bioavailability and metabolism of ellagitannins in humans[J]. Journal of Agricultural and Food Chemistry,2007,55(25):10476−10485. doi: 10.1021/jf0723864
    [76]
    BIALONSKA D, SASHI G, KEVIN K, et al. The effect of pomegranate (Punica granatum L.) byproducts and ellagitannins on the growth of human gut bacteria[J]. Journal of Agricultural and Food Chemistry,2009,57(18):8344−8349. doi: 10.1021/jf901931b
    [77]
    KANG I, BUCKNER T, SHAY N F, et al. Improvements in metabolic health with consumption of ellagic acid and subsequent conversion into urolithins: Evidence and mechanisms[J]. Advances in Nutrition (Bethesda, Md.),2016,7(5):961−972. doi: 10.3945/an.116.012575
    [78]
    BASTIDA J, TRUCHADO P, LARROSA M, et al. Urolithins, ellagitannin metabolites produced by colon microbiota, inhibit Quorum Sensing in Yersinia enterocolitica: Phenotypic response and associated molecular changes[J]. Food Chemistry,2012,132(3):1465−1477. doi: 10.1016/j.foodchem.2011.12.003
    [79]
    徐冰, 张聪恪, 王海玉, 等. 覆盆子提取物祛黄褐斑作用研究[J]. 中国实用医药,2012,7(8):24−25. [XU B, ZHANG C K, WANG H Y, et al. Study on the effect of removing chloasma of Raspberry extract[J]. China Prac Med,2012,7(8):24−25. doi: 10.3969/j.issn.1673-7555.2012.08.011

    XU B, ZHANG C K, WANG H Y, et al. Study on the effect of removing chloasma of Raspberry extract[J]. China Prac Med, 2012, 7(8): 24-25. doi: 10.3969/j.issn.1673-7555.2012.08.011
    [80]
    赵慧, 张学顺, 戴衍朋, 等. 炮制对地榆中鞣质类成分含量及凝血作用的影响[J]. 山东农业科学,2018,50(12):127−131. [ZHAO H, ZHANG X S, DAI Y P, et al. Effect of processing on content of tannins and blood coagulation in Sanguisorba officinalis L

    J]. Shandong Agricultural Sciences,2018,50(12):127−131.
    [81]
    仲丽丽, 于颖, 易娅静, 等. 鞣花酸对阿尔茨海默病小鼠学习和记忆能力的影响及其分子机制[J]. 山东医药,2020,60(35):38−41. [ZHONG L L, YU Y, YI Y J, et al. Effect of ellagic acid on learning and memory of mice with Alzheimer’s disease and its molecular mechanism[J]. Shandong Medical Journal,2020,60(35):38−41. doi: 10.3969/j.issn.1002-266X.2020.35.009

    ZHONG L L, YU Y, YI Y J, et al. Effect of ellagic acid on learning and memory of mice with Alzheimer’s disease and its molecular mechanism[J]. Shandong Medical Journal, 2020, 60(35): 38-41. doi: 10.3969/j.issn.1002-266X.2020.35.009
    [82]
    焦士蓉, 唐子尧, 孙博瑞, 等. 石榴皮提取物和鞣花酸对人脂肪干细胞增殖和分化的影响[J]. 西华大学学报(自然科学版),2019,38(2):48−51. [JIAO S R, TANG Z R, SUN B R, et al. Effect of pomegranate peel extract and ellagic acid on human adipose-derived cells proliferation and differentiation[J]. Journal of Xihua University (Natural Science Edition),2019,38(2):48−51.

    JIAO S R, TANG Z X, SUN B R, et al. Effect of pomegranate peel extract and ellagic acid on human adipose - derived cells proliferation and differentiation[J]. Journal of Xihua University (Natural Science Edition), 2019, 38(2): 48-51.

Catalog

    Article Metrics

    Article views (735) PDF downloads (98) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return