Dose-effect analysis of taurine in improving glucose metabolism

Purpose: The dose-effect relationship of taurine in improving glucose metabolism in domestic and foreign literatures in the past 20 years were analyzed to provide references for the development of taurine-related functional foods and special medical foods.Method: Based on CNKI, Pub-Med database, all the papers ( 1996-2015) with " taurine hypoglycemic " were retrieved, and the literatures related to " taurine and fasting blood glucose" were further searched. 466 related articles were retrieved out, and 61 articles were related to the hypoglycemic effect of taurine. Results: For STZ-induced diabetic rats, blood sugar was significantly reduced by 0.5% taurine drinking water or 1% taurine diet for 12 weeks or 3% taurine drinking water for 2 weeks.For ALX-induced diabetic rats, blood sugar was effectively decreased by 1% taurine drinking water for 1 week.For high glucose and high fat diet induced diabetic rats, intake of 1% taurine drinking water for 30 days notably reduced blood sugar, and an appropriate increase in taurine dose was beneficial to reduce the blood sugar. Blood sugar was decreased in diabetic mice by 2% taurine drinking water or low dose intraperitoneal injection of taurine for 3⁴ weeks.For different ALXinduced diabetic rabbits, 3 weeks of 1% taurine drinking water significantly decreased blood sugar. After 40 days intake of1.5% taurine aqueous solution, the blood sugar of male newborn rats was significantly reduced. The intake of 3% taurine drinking water for 9 weeks or gavage of 0.2 g/kg/d dose of taurine to make blood sugar significantly decreased in OLETF rats.Daily intake of 12 g taurine for 3 weeks make the decline of blood sugar in diabetic pregnant women.Conclusion: The decrease of blood glucose is closely related to the experimental period and dose of taurine, and it is also affected by factors such as the experimental object and its physiological state, modeling method and intake mode.