Research progress in soy isoflavones on prostate cancer and the underlying mechanism

Soy isoflavone belongs to flavonoids and widely distributed in the bean pods plants. Epidemiological studies have shown that soy isoflavones can exert the function of anti- prostate cancer,which is related to inducing apoptosis and inhibiting growth proliferation of PCa cells,enhancing radio and chemotherapeutic agents,regulating of DNA repair and methylation and antagonism of androgen- mediated signaling pathways. In this paper,the research of soy isoflavones against prostate cancer and the underlying mechanism was summarized.