Effects of edamame on blood glucose and blood lipid in type 2 diabetic mellitus mice

Objective:To study the effect of edamame on blood glucose and blood lipids in (streptozotocin (STZ) -induced ICR diabetic mice. Methods:Models of type 2 diabetes mellitus (T2DM) mice) were induced by high fat chow and intraperitoneal injection of streptozotocin (STZ) , and were divided into different groups, which were given High dose of 4.35g/kg Edamame, low dose of 2.20g/kg Edamame and metformin respectively. Results: After 28d drug administration, symptoms of diabetic mice fed a dose of 2.20g/kg edamame were alleviated obviously. the level of blood glucose in this group decreased by 29.78% and the area under the curve (AUC) decreased by 12.52%. Compared with the model group, the levels of TC and TG in this group were lowered remarkably (p <0.05) . Conclusion:Edamame might be related to improving hypoglycemic and hypolipidemic effect in type 2 diabetic mellitus mice.