均匀设计法优化葛根素白蛋白微球处方工艺

周婷; 余彩英; 吴卫; 奉建芳

doi:10.13386/j.issn1002-0306.2019.04.023

均匀设计法优化葛根素白蛋白微球处方工艺

周婷¹,
余彩英¹,
吴卫^1, ,,
奉建芳^1,2

1. 桂林医学院药学院, 广西桂林 541004;
2. 广西中医药大学药学院, 广西南宁 530200

基金项目:

国家自然科学基金项目(81760704,81573623)

广西自然科学基金项目(2016GXNSFAA380081)。

详细信息

作者简介:
周婷(1994-),女,硕士研究生,研究方向:药物研发与转化,E-mail:18276359871@163.com。

通讯作者:
吴卫(1982-),男,博士,研究员,研究方向:药物研发与转化,E-mail:wuwei_2007@126.com。

中图分类号: TS255.1
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出版历程
- 收稿日期: 2018-06-07
- 网络出版日期: 2020-11-12
- 刊出日期: 2019-02-14

Optimised Formulation of Puerarin Albumin Microsphere by Uniform Design

1. School of Pharmacy, Guilin Medical University, Guilin 541004, China;
2. School of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, China

摘要

摘要: 为优化葛根素白蛋白微球处方工艺。以牛血清白蛋白为载体,采用乳化热固化法制备葛根素白蛋白微球。以包封率和载药量为综合评价指标,以牛血清白蛋白用量、葛根素用量、司盘80用量为考察因素,在单因素实验的基础上,利用均匀设计法优化葛根素白蛋白微球的处方工艺。葛根素白蛋白微球最优处方为:牛血清白蛋白0.20 g,葛根素30.00 mg,司盘80为0.80 mL,验证处方的包封率为76.75%±2.09%,载药量为9.81%±0.14%。采用均匀设计优化法制备的葛根素白蛋白微球综合评分高,模型预测性良好。
- 葛根素 /
- 白蛋白微球 /
- 处方优化 /
- 均匀设计
Abstract: To optimize the formulation of puerarin albumin microspheres. The microspheres were prepared by emulsion-heat stabilization techniques using albumin as carrier. The encapsulation efficiency and drug loading rate of the puerarin albumin microspheres were selected as comprehensive evaluation indexes. The amount of bovine serum albumin, the amount of puerarin and the amount of span-80 were selected as factors.Uniform design method were used to optimize the formulation process of puerarin albumin microspheres. Optimum formulation of puerarin albumin microspheres was as follows:Bovine serum albumin was 0.20 g, puerarin was 30.00 mg, span-80 was 0.80 mL. The entrapment efficiency of optimum formulation was 76.75%±2.09% and the drug loading was 9.81%±0.14%. The formulation process of the puerarin albumin microspheres optimized by uniform design method was effective and feasible with a good prediction, and the results showed a high comprehensive score.
- puerarin /
- albumin microspheres /
- prescription optimization /
- uniform design