Progress in foodborne phytochemical in preventing and curing neurodegenerative diseases
-
摘要: 神经退行性疾病是一种由于大脑和脊髓细胞神经元及其髓鞘丧失而导致的神经元功能障碍的状态。研究表明,一些食源性植物化学物如白藜芦醇、原花青素、人参皂苷具有抗氧化、抗脂质过氧化、神经保护等作用,对神经退行性疾病的防治有一定作用。本文就一些常见的、易于获得的食源性植物化学物对神经退行性疾病的保护作用的研究进展作一综述。Abstract: Neurodegenerative diseases are caused by the loss of neurons and myelin in brain and spinal cord,and result in neuronal dysfunction. Researchs show that foodborne phytochemicals, such as resveratrol,proanthocyanidins,ginsenosides have antioxidant,anti- lipid peroxidation,neuroprotective effects and exhibit effect on prevention and treatment of neurodegenerative diseases.In this paper,the recent studies of the protective effect of foodborne phytochemicals which are common and available on neurodegenerative diseases were reviewed.
-
Keywords:
- foodborne phytochemicals /
- natural /
- neurodegenerative disease /
- oxidative stress
-
[1] Badshah H,Kim T H,Kim M O.Protective effects of anthocyanins against amyloid beta-induced neurotoxicity in vivo and in vitro[J].Neurochemistry International,2015,80:51-59.
[2] Levesque D,Rouillard C.Nur77 and retinoid X receptors:crucial factors in dopamine-related neuroadaptation[J].Trends in Neuroscience,2007,30(1):22-30.
[3] Park J H,Jung J W,Ahn Y J,et al.Neuroprotective properties of phytochemicals against paraquat-induced oxidative stress and neurotoxicity in Drosophila melanogaster[J].Pesticide Biochemistry and Physiology,2012,104(2):118-125.
[4] Valenzano D R,Terzibasi E,Genade T,et al.Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate[J].Current Biology,2006(3),16:296-300.
[5] Fukui M,Choi H J,Zhu B T.Mechanism for the protective effect of resveratrol against oxidative stress-induced neuronal death[J].Free Radical Biology Medicine,2010,49:800-813.
[6] Panickar K S,Polansky M M,Anderson R A.Cinnamon polyphenols attenuate cell swelling and mitochondrial dysfunction following oxygen-glucose deprivation in glial cells[J].Experimental Neurology,2009,216(5):420-427.
[7] Cao H,Urban J F,Anderson R A.Cinnamon polyphenol extract affects immune responses by regulating anti-and proinflammatory and glucose transporter gene expression in mouse macrophages[J].The Journal of Nutrition,2008,138(5):833-840.
[8] Wu J X,Li Q,Wang X Y,et al.Neuroprotection by curcumin in ischemic brain injury involves the Akt/Nrf2 pathway[J].PLo S One,2013,8(3):e59843.
[9] Kaizer J,Barath G,Csonka R,et al.Catechol oxidase and phenoxazinone synthase activity of a manganese(Ⅱ)isoindoline complex[J].Journal of Inorganic Biochemistry,2008,102:773-780.
[10] Guan S,Zhang X L,Ge D,et al.Protocatechuic acid promotes the neuronal differentiation and facilitates survival of phenotypes differentiated from cultured neural stem and progenitor cells[J].European Journal of Pharmacology,2011,670(4):471-478.
[11] Kim H J,Lee K W,Kim M S,et al.Piceatannol attenuates hydrogen-peroxide-and peroxynitrite-induced apoptosis of PC12 cells by blocking down-regulation of Bcl-XLand activation of JNK[J].Journal of Nutritional Biochemistry,2008,19(7):459-466.
[12] Liu C M,Ma J Q,Liu S S,et al.Proanthocyanidins improves lead-induced cognitive impairments by blocking endoplasmic reticulum stress and nuclear factor-κB-mediated inflammatory pathways in rats[J].Food and Chemical Toxicology,2014,72:295-302.
[13] Wang S W,Wang Y J,Su Y J,et al.Rutin inhibitsβ-amyloid aggregation and cytotoxicity,attenuates oxidative stress,and decreases the production of nitric oxide and proinflammatory cytokines[J].Neurotoxicology,2012,33(3):482-490.
[14] Pavlica S,Gebhardt R.Protective effects of flavonoids and two metabolites against oxidative stress in neuronal PC12 cells[J].Life Science,2010,86(3):79-86.
[15] Zhang Y F,Yi B,Ma J H,et al.Quercetin promotes neuronal and behavioral recovery by suppressing inflammatory response and apoptosis in a rat model of intracerebral hemorrhage[J].Neurochemistry Research,2015,40(1):195-203.
[16] Yu X,Wang L N,Ma L,et al.Akebia saponin D attenuates ibotenic acid-induced cognitive deficits and pro-apoptotic response in rats:Involvement of MAPK signal pathway[J].Behavioural Brain Research,2012,101(3):479-486.
[17] Wang Y C,Kan H W,Yin Y Y,et al.Protective effects of ginsenoside Rg1 on chronic restraint stress induced learning and memory impairments in male mice[J].Pharmacology,Biochemistry and Behavior,2014,120:73-81.
[18] Song X Y,Hu J F,Chu S F,et al.Ginsenoside Rg1 attenuates okadaic acid induced spatial memory impairment by the GSK3β/tau signaling pathway and the Aβformation prevention in rats[J].European Journal of Pharmacology,2013,710(1):29-38.
[19] Chu S H,Gu J F,Feng L,et al.Ginsenoside Rg5 improves cognitive dysfunction and beta-amyloid deposition in STZinduced memory impaired rats via attenuating neuroinflammatory responses[J].International Immunopharmacology,2014,19(2):317-326.
[20] Zhang M,Ning G,Shou C,et al.Inhibitory effect of jujuboside A on glutamate-mediated excitatory signal pathway in hippocampus[J].Planta Medica,2003,69(8):692-695.
[21] You Z,Xia Q,Liang F,et al.Effects on the expression of GABAAreceptor subunits by jujuboside A treatment in rat hippocampal neurons[J].Journal of Ethnopharmacology,2010,128(2):419-423.
[22] Tiwari M,Kakkar P.Plant derived antioxidants-geraniol and camphene protect rat alveolar macrophages against t-BHP induced oxidative stress[J].Toxicology in vitro,2009(2),23:295-301.
[23] Prasad S N,Muralidhara.Neuroprotective effect of geraniol and curcumin in an acrylamide model of neurotoxicity in Drosophila melanogaster:Relevance to neuropathy[J].Journal of Insect Physiology,2014,60:7-16.
[24] Rekha K R,Selvakumar G P.Gene expression regulation of Bcl2,Bax and cytochrome-C by geraniol on chronic MPTP/probenecid induced C57BL/6 mice model of Parkinson's disease[J].Chemico-Biological Interactions,2014,217:57-66.
[25] Barros M P,Poppe S C,Bondan E F.Neuroprotective properties of the marine carotenoid astaxanthin and omega-3 fatty acids,and perspectives for the natural combination of both in krill oil[J].Nutrients,2014,6(3):1293-1317.
[26] Zhang Y R,Wang W,Hao C,et al.Astaxanthin protects PC12 cells from glutamate-induced neurotoxicity through multiple signaling pathways[J].Journal of Functional Foods,2015,16:137-151.
[27] Chang C S,Chang C L,Lai G H.Reactive oxygen species scavenging activities in a chemiluminescence model and neuroprotection in rat pheochromocytoma cells by astaxanthin,beta-carotene,and canthaxanthin[J].Kaohsiung Journal of Medical Sciences,2013,29(8):412-421.
[28] Ye Q Y,Zhang X D,Huang B X,et al.Astaxanthin suppresses MPP+-induced oxidative damage in PC12 cells through a Sp1/NR1 signaling pathway[J].Marine Drugs,2013,11(4):1019-1034.
[29] Yoo D Y,Kim W,Nam S M,et al.Neuroprotective effects of Z-ajoene,an organosulfur compound derived from oil-macerated garlic,in the gerbil hippocampal CA1 region after transient forebrain ischemia[J].Food and Chemical Toxicology,2014,72:1-7.
[30] 辛天蓉,刘燕强,吕宪禹,等.大豆异黄酮对小鼠脑组织中胆碱酯酶和氨基酸类神经递质及记忆的影响[J].南开大学学报,自然科学版,2005,38(6):18-21. [31] 龙军,张良,袁冬平,等.大豆异黄酮对脑缺血再灌注大鼠海马神经再生的影响[J].南京中医药大学学报,2011,27(1):49-54. [32] Hsieh P F,Hou C W,Yao P W,et al.Sesamin ameliorates oxidative stress and mortality in kainic acid-induced status epilepticus by inhibition of MAPK and COX-2 activation[J].Journal of Neuroinflammation,2011,8(57):57-66.
[33] Zhang M,Lee H J,Park K H,et al.Modulatory effects of sesamin on dopamine biosynthesis and L-dopa-induced cytotoxicity in PC12 cells[J].Neuropharmacology,2012,62(7):2219-2226.
[34] Bournival J,Plouffe M,Renaud J,et al.Quercetin and sesamin protect dopaminergic cells from MPP+-induced neuroinflammation in a microglial(N9)-neuronal(PC12)coculture system[J].Oxidative Medicine and Cellular Longevity,2012,2012 doi: 10.1155/2012/921941.
[35] Ahmad S,Elsherbiny N M,Haque R,et al.Sesamin attenuates neurotoxicity in mouse model of ischemic brain stroke[J].Neurotoxicology,2014,45:100-110.
[36] Tim V,Jeroen F J,Jo M,et al.Plant sterols:Friend or foe in CNS disorders?[J].Progress Lipid Research,2015,58:26-39.
[37] 余焕玲,毕研霞,肖荣,等.β-谷固醇对高脂饲料喂养小鼠空间学习记忆能力的影响[J].首都医科大学学报,2008,29(6):724-727. [38] Albena T,Dinkova K,Rumen V.Glucosinolates and isothiocyanates in health and disease[J].Trends Mol Med,2012,18(6):337-347.
[39] 曾潍贤,陈大庆,邢超,等.萝卜硫素对大鼠局灶性脑缺血再灌注损伤的脑保护作用[J],医学研究杂志,2013,42(10):120-123. [40] 魏晓珉,闫凤凤,鄂蒙,等.钙蛋白酶抑制剂对丙烯酰胺中毒大鼠神经毒性的拮抗作用[J].环境与健康,2014,31(012):1045-1047. [41] Lee E,Eom J E,Kim H L,et al.Effect of conjugated linoleic acid,μ-calpain inhibitor,on pathogenesis of Alzheimer's disease[J].Biochim Biophys Acta,2013,1831(4):709-718.
计量
- 文章访问数:
- HTML全文浏览量:
- PDF下载量:
下载:
