Progress of fatty acid metabolism and skeletal muscle contraction genes affecting lamb quality
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摘要: 肉质受到多种因素的影响,遗传因素中的基因对肉质的调控起主导作用。脂肪酸代谢和骨骼肌收缩与肉的风味、嫩度和肌纤维的密度存在密切相关性,进而影响肌间脂肪的蓄积、肌肉纤维的发育和肌肉含水率等肉质性状。本文主要对影响脂肪酸代谢的脂素1基因、二乙酰基甘油酰基转移酶1基因、脂肪组织甘油三酯水解酶基因和影响骨骼肌收缩的骨骼肌快速肌钙蛋白基因、原肌球蛋白3基因的功能及其对肉质的调控机理进行介绍,并对基因影响肉质的研究现状进行综述。Abstract: Meat traits were effected by many factors,and the genes play an important role in genetic factors.Fatty acid metabolism and skeletal muscle contraction were related with the flavor and tenderness of muscle,diameter and density of muscle fiber which influence accumulation of the intermuscular fat,development of muscle fiber,the moisture of muscle and so on. The function,regulation mechanism and research status on meat quality of qualityfat-1 gene,diethyl diacylglycerol acyltransferase 1 gene,adipose tissue triglyceride hydrolase gene,skeletal muscle troponin fast gene,tropomyosin 3 gene were reviewed in this article.
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Keywords:
- meat traits /
- genes /
- fatty acid metabolism /
- skeletal muscle contraction /
- lamb
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[1] Lefaucheur L.A second look into fibre typing-relation to meat quality[J].Meat Science,2010,84(2):257-270.
[2] 徐秋良.绵羊三个肉质性状候选基因的序列特征,多态性及发育性表达规律研究[D].杨凌:西北农林科技大学,2008. [3] 牛茂源.LPIN1基因多态性与奶牛脂肪肝的相关性分析[D].泰安:山东农业大学,2014. [4] Csaki L S,Dwyer J R,Li X,et al.Lipin-1 and lipin-3together determine adiposity in vivo[J].Molecular Metabolism,2014,3(2):145-154.
[5] Li S,Chen W,Kang X,et al.Distinct tissue expression profiles of chicken Lpin1-α/βisoforms and the effect of the variation on muscle fiber traits[J].Gene,2013,515(2):281-290.
[6] Péterfy M,Phan J,Xu P,et al.Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein,lipin[J].Nature Genetics,2001,27(1):121-124.
[7] He X P,Xu X W,Zhao S H,et al.Investigation of LPIN1 as a candidate gene for fat desposition in pigs[J].Mol Biol Rep,2009,36(5):1175-1180.
[8] Zhang S P,Li S Y,Chen W,et al.A single-nucleotide polymorphism in the 3′untranslated region of the LPIN1 gene and association analysis with performance traits in chicken[J].British Poultry Science,2013,54(3):312-318.
[9] 魏琳琳,高晋生,王景霖,等.绵羊LPIN1基因的克隆和m RNA表达研究[J].畜牧兽医学报,2013,44(9):1371-1379. [10] 戈新,邢晋祎,刘忠琛,等.6个猪群Lpin1基因多态性分析[J].西南农业学报,2011,24(1):301-304. [11] 卫利选,常振华,何诚,等.LPIN1基因多态性与黄牛经济性状的关联研究[J].西北农业学报,2012,21(1):11-15. [12] 国欣,柳蓓蓓,马族啸,等.二酰基甘油酰基转移酶1抑制剂的研究进展[J].中国药物化学杂志,2014,24(2):157-164. [13] 杨具田,臧荣鑫,徐红伟,等.甘南藏系绵羊DGAT1基因16-17外显子多态性分析[J].畜牧兽医学报,2011,42(6):875-879. [14] 王国富,吴慧光,孙国权,等.中国西门塔尔牛DGAT1和DGAT2基因组织表达谱及其在脂肪组织中的表达与背膘厚的关联分析[J].华北农学报,2012,27(5):60-64. [15] Jeong J,Kwon E G,Im S K,et al.Expression of fat deposition and fat removal genes is associated with intramus-cular fat content in longissimus dorsi muscle of Korean cattle steer[J].J Anim Sci,2012,20:2044-2053.
[16] Anton I,Kovács K,HollóG,et al.Effect of leptin,DGAT1and TG gene polymorphisms on the intramuscular fat of Angus cattle in Hungary[J].Livestock Science,2011,135(2):300-303.
[17] Curi R A,Chardulo L A L,Arrigoni M D B,et al.Associations between LEP,DGAT1 and FABP4 gene polymorphisms and carcass and meat traits in Nelore and crossbred beef cattle[J].Livestock Science,2011,135(2):244-250.
[18] Cui J X,Zeng Y Q,Wang H,et al.The effects of DGAT1and DGAT2 m RNA expression on fat deposition in fatty and lean breeds of pig[J].Livestock Science,2011,140(1):292-296.
[19] Zimmermann R,Strauss J G,Haemmerle G,et al.Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase[J].Science,2004,306(5700):1383-1386.
[20] Jenkins C M,Mancuso D J,Yan W,et al.Identification,cloning,expression,and purification of three novel human calcium independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities[J].J Biol Chem,2004,279(47):48968-48975.
[21] Bong J J,Jeong J Y,Rajasekar P,et al.Differential expression of genes associated with lipid metabolism in longissimus dorsi of Korean bulls and steers[J].Meat Science,2012,91(3):284-293.
[22] Nagy H M,Paar M,Heier C,et al.Adipose triglyceride lipase activity is inhibited by long-chain acyl-coenzyme A[J].Biochimica et Biophysica Acta(BBA)-Molecular and Cell Biology of Lipids,2014,1841(4):588-594.
[23] Jocken J W E,Smit E,Goossens G H,et al.Adipose triglyceride lipase(ATGL)expression in human skeletal muscle is type I(oxidative)fiber specific[J].Histochemistry and Cell Biology,2008,129(4):535-538.
[24] 刘文彦.绵羊ATGL基因克隆,遗传变异和表达的研究[D].太谷:山西农业大学,2014. [25] 滕炎玲.西农萨能奶山羊ATGL与HSL基因的c DNA克隆,序列分析与表达研究[D].杨凌:西北农林科技大学,2010. [26] Li J,Luo J,Wang H,et al.Adipose triglyceride lipase regulates lipid metabolism in dairy goat mammary epithelial cells[J].Gene,2015,554(1):125-130.
[27] Li Y,Chen Y,Li J,et al.Molecular characterization,expression profile and polymorphisms of the porcine TNNC2 gene[J].Hereditas,2008,145(6):274-282.
[28] Farah C S,Reinach F C.The troponin complex and regulation of muscle contraction[J].The FASEB Journal,1995,9(9):755-767.
[29] 徐秋良,崔锦,朱宽佑,等.不同TNNC2基因型滩羊骨骼肌中TNNC2的表达量分析[J].黑龙江畜牧兽医,2015(2):13. [30] 陈浩林.天府肉羊TNNC1,TNNC2,TNNT3基因克隆及其组织表达测定[D].雅安:四川农业大学,2012. [31] Oe M,Ohnishi-Kameyama M,Nakajima I,et al.Muscle type specific expression of tropomyosin isoforms in bovine skeletal muscles[J].Meat Science,2007,75(4):558-563.
[32] Lees-Miller J P,Helfman D M.The molecular basis for tropomyosin isoform diversity[J].Bioessays,1991,13(9):429-437.
[33] 梁如意,李岩,唐中林,等.TPM1基因在猪背最长肌生长发育过程中的动态表达[J].中国农业科学,2012,45(11):2267-2272. [34] Vrhovski B,ThézéN,Thiébaud P.Structure and evolution of tropomyosin genes[M].Tropomyosin.Springer New York,2008:6-26.
[35] 崔静,李太武,苏秀榕,等.南移养殖的刺参(Apostichopus japonicus)c DNA文库的构建及原肌球蛋白基因的研究[J].海洋与湖沼,2010(6):850-856. [36] 杨静娴,林原.原肌球蛋白的分子生物学研究进展[J].大连医科大学学报,2004,26(2):144-147. [37] Pieples K,Wieczorek D F.Tropomyosin 3 increases striated muscle isoform diversity[J].Biochemistry,2000,39(28):8291-8297.
[38] 叶保国,张小辉,徐铁山.北京鸭和淮南麻鸭胸肌发育过程TPM1和TPM3基因的表达变化研究[J].黑龙江畜牧兽医,2014,19:22. [39] 谢水华,李加琪,朱良瑞,等.猪TPM3基因内含子1的序列分析[C].第十次全国畜禽遗传标记研讨会论文集,2006.
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