Removing salt by ethanol precipitatation and nanofiltration to preparation gluconic acid
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摘要: 比较制备葡萄糖酸中两种脱盐方法。在葡萄糖酸钠与盐酸反应后,分别采用乙醇沉淀和纳滤脱盐制备葡萄糖酸的工艺。在研究葡萄糖酸钠与盐酸的料液比、乙醇的体积分数、静置时间等单因子对葡萄糖酸产率及脱盐效果影响的基础上,通过正交实验确定了乙醇沉淀法脱盐的最佳工艺条件:料液比1∶2 g/m L、乙醇体积分数75%、静置时间24 h,葡萄糖酸产率最高达到61.09%,脱盐率为80.44%。纳滤(10 L溶液)脱盐的最佳工艺为:采用截留分子量150 u的纳滤膜(膜面积为0.25 m2),在0.3 MPa压力,温度30℃下浓缩110 min,葡萄糖酸的截留率为85.99%,膜通量为10.01 L/m2h,浓缩四次,脱盐率为78.66%。两种脱盐方法均有较高的脱盐率,纳滤脱盐法较乙醇沉淀盐法更好。Abstract: Two desalination methods were compared in preparation of gluconate. Ethanol precipitation and nanofiltration were respectively investigated to remove sodium chloride in the reaction mixture of sodium gluconate and hydrochloric acid. The optimal technology of ethanol precipitation was obtained by the orthogonal test. Effects of sodium gluconate to hydrochloric acid ratio,volume fraction of ethanol and incubation time on the yield of gluconic acid and desalinization ratio were investigated under single factor test. The results showed that it yielded 61.09% of gluconic acid and removed 80.44% of salt under the following optimal condition:one part of sodium gluconate was reacted with 2 volume of HCl(in equimolar ratio),and then ethanol was added to 75%(final concentration) and incubated at room temperature for 24 h. The optimal nanofiltration(150 D molecular cut-off) technology was:10.0 L solution was nanofiltrated at 0.3 MPa and 30 ℃ for 110 min.Under this condition,85.99% of gluconic acid was recovered,10.01 L/m2 h of membrane flux was produced and78.66% of salt was removed after nanofiltrated for four rounds. Two methods of desalination had high desalination rate,nanofiltration was better than ethanol precipitation.
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Keywords:
- gluconic acid /
- orthogonal test /
- nanofiltration /
- desalinization ratio
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