Effect of plant polyphenols on anti-osteoporosis
-
摘要: 骨质疏松症是一个全球性的问题。目前国内外使用的药物虽有一定疗效,但存在安全隐患、价格昂贵等问题。近年来,国内外学者的研究主要集中在从植物中提取天然有效成分。现就4种重要的植物多酚和有效成分在抗骨质疏松方面的研究概况及其作用机制作一介绍,为寻找安全有效的抗骨质疏松药物提供参考。Abstract: Osteoporosis is a global problem.Although the drugs have curative effect, they still have the security risk and high prices problem. In recent years, scholars always focused on natural active ingredients extracted from plant.In this review, four kinds of important plant polyphenols, the present situation of their anti-osteoporosis activity and interaction mechanisms were summarized, in order to find some new anti-osteoporosis drugs, which were also safe and effective.
-
Keywords:
- plant polyphenons /
- osteoporosis /
- reactive oxygen species /
- estrogen /
- anti-inflammatory
-
[1] Shen C L, Chyu M C, Cao J J, et al.Green tea polyphenols improve bone microarchitecture in high-fat-diet-induced obese female rats through suppressing bone formation and erosion[J].Journal of Medicinal Food, 2013, 16 (5) :421-427.
[2] Oka Yoshiomi, Iwai Shinichi, Amano Hitoshi, et al.Tea polyphenols inhibit rat osteoclast formation and differentiation[J].Journal of Pharmacological Sciences, 2012, 118 (1) :55-64.
[3] Shen C L, Yehc J K, Christina Samathanama, et al.Protective actions of green tea polyphenols and alfacalcidol on bone microstructure in female rats with chronic inflammation[J].Journal of Nutritional Biochemistry, 2011, 22:673-680.
[4] Shen C L, Yeh J K, Gao J J, et al.Green tea polyphenols mitigate bone loss of female rats in a chronic inflammationinduced bone loss model[J].J Nutr Biochem, 2010, 21 (10) :968-974.
[5] Wong RWK, Rabie ABM.Effect of quercetin on preosteoblasts and bone defects[J].The Open Orthopaedics Journal, 2008, 2 (1) :27-32.
[6] Liang Wei, Luo Zhonghua, Ge Shuhua.Oral administration of quercetin inhibits bone loss in rat model of diabetic osteopenia[J].European Journal of Pharmacology, 2011, 670 (1) :317-324.
[7] Derakhshanian H, Djalali M, Djazayery A, et al.Quercetin prevents experimental glucocorticoid-induced osteoporosis:a comparative study with alendronate[J].Canadian Journal of Physiology and Pharmacology, 2013, 91 (5) :380-385.
[8] Derakhshanian H, Ghadbeigi S, Rezaian M, et al.Quercetin improves bone strength in experimental biliary cirrhosis[J].Hepatology Research, 2013, 43 (4) :394-400.
[9] Sehmisch S, Hannner F, Christoffel J, et al.Comparison of the phytohormones genistein, resveratrol and 8-prenylnaringenin as agents for preventing osteoporosis[J].Planta Med, 2008, 74 (8) :794-801.
[10] Lai C Y, Yang J Y, Rayalam S, et al.Preventing bone loss and wetght gain with combinations of vitaminD and phytochemicals[J].J Med F00d, 201l, 14 (11) :1352-1362.
[11] Habold C, Momken I, Ouadi A, et al.Effect of prior treatment with resveratrol on density and structure of rat long bones under tail-suspension[J].J Bone Miner Metab, 2011, 29 (1) :15-22.
[12] Fistonic I, Situm M, Bulat V, et al.Olive oil biophenols and women's health[J].Medicinski Glasnik, 2012, 9 (1) :1-9.
[13] Keitaro H, Tadashi G, Masahiro A, et al.Olive polyphenol hydroxytyrosol prevents bone loss[J].European Journal of Pharmacology, 2011, 622:78-84.
[14] Caroline P, Julie M, Apostolis A, et al.Major phenolic compounds in olive oil modulate bone loss in an ovariectomy/inflammation experimental model[J].J Agric Food Chem, 2008, 56, 9417-9422.
[15] Shen C L, Vera V B, Chyu M C.Fruits and dietary phytochemicals in bone protection[J].Nutrition Research, 2012, 32 (12) :897-910.
[16] Almeida M.Aging and oxidative stress-A new look at old bone[J].IBM Bone Key, 2010, 7 (10) :340-352.
[17] Monroe D G, McGee-Lawrence M E, Oursler M J, et al.Update on Wnt signaling in boen cell biology and bone disease[J].Gene, 2012, 492 (1) :1-18.
[18] Tanaka H, Mine T, Ogasa H, et al.Expression of RANKL/OPG during bone remodeling in vivo[J].Biochem Biophys Res Commun, 2011, 411 (4) :690-694.
[19] Takahashi N, Maeda K, Ishihara A, et al.Regulatory mechanism of osteoclastogenesis by RANKL and Wnt signals[J].Front Biosci, 2011, 16:21-30.
[20] 杨亚军, 崔燎, Yang Ya-Jun, 等.FoxO/Wnt通路在氧化应激介导的骨质疏松中的调控机制[J].中国药理学通报, 2013, 29 (1) :27-30. [21] Shen C L, Yeh J K, Stoecker B J, et al.Green tea polyphenols mitigate deterioration of bone microarchitecture in middle-aged female rats[J].Bone, 2009, 44 (4) :684-690.
[22] Bellion P, Digles J, Will F, et al.Polyphenolic apple extracts:effects of raw material and production method on antioxidant effectiveness and reduction of DNA damage in caco-2 cells[J].J Agric Food Chem, 2010, 58 (11) :6636-6642.
[23] Baek K H, Oh K W, Lee W Y, et al.Association of oxidative stress with postmenopausal osteoporosis and the effects of hydrogen peroxide on osteoclast formation in human bone marrow cell cultures[J].Calcif Tissue Int, 2010, 87 (3) :226-235.
[24] Wang H D, Shi Y M, Li L, et al.Treatment with resveratrol attenuates sublesional bone loss in spinal cord-injured rats[J].British Journal of Pharmacology, 2013, 170 (4) :796-806.
[25] Lee K, Jessop H, Suswillo R, et al.Endocrinology:bone adaptation requires oestrogen receptor-alpha[J].Nature, 2003, 424 (6947) :389.
[26] Su J L, Yang C Y, Zhao M, et al.Forkhead proteins are critical for bone morphogenetic protein-2 Regulation and antitumor activity of resveratrol[J].J Biol Chem, 2007, 282 (27) :19385-19398.
[27] Tseng P C, Hou S M, Chen R J, et al.Resveratrol promotes osteogenesis of human mesenchymal stem cells by upregulating RUNX2 gene expression via the SIRT1/FOXO3A axis[J].Journal of Bone and Mineral Reserch, 2011, 26 (10) :2552-2563.
[28] Holloway K R, Calhoun T N, Saxena M, et al.SIRT1regulates dishevelled proteins and promotes transient and constitutive Wnt signaling[J].Proc Natl Acad Sci USA, 2010, 107 (20) :9216-9221.
[29] Chen Lulu, Wang Suxing, Dai Yu, et al.Effect of catch-up growth by various dietary patterns and resveratrol intervention on bone status[J].Experimental Biology and Medicine, 2012, 237 (3) :297-304.
[30] Shakibaei M, Buhrmann C, Mobasheri A, et al.Resveratrolmediated SIRT-1 interactions with p300 modulate receptor activator of NF-kappa B ligand (RANKL) activation of NF-kappa B signaling and inhibit osteoclastogenesis in bone-derived cells[J].Journal of Biological Chemistry, 2011, 286 (13) :11492-11505.
计量
- 文章访问数: 147
- HTML全文浏览量: 18
- PDF下载量: 311